One or more photo(s) has been virtually staged. Tucked away on more than 2.5 acres less than a mile from UF and Shands, this one-of-a-kind property offers the serenity of a nature preserve right in the heart of Gainesville. Perched high above Hogtown Creek, the home captures sweeping, tree-top views and complete privacy - a rare combination of acreage, location, and natural beauty. Step inside to a dramatic two-story great room wrapped in cedar batten-and-board with a striking Spade stone fireplace that anchors the space and frames the view beyond. Walls of windows blur the line between indoors and out, filling every room with light and a connection to the surrounding preserve. The main level features a formal living room with bay windows, a spacious dining room with custom built-ins, and an island kitchen with double ovens and breakfast area opening to the pool deck. The primary suite is a peaceful retreat overlooking the pool and wooded backdrop, while upstairs offers five additional bedrooms (two of which have ensuite bathrooms) plus an office and game room - plenty of space for family, guests, or multi-generational living. Recent updates include a NEW 2024 roof, newer water heaters, fresh interior and exterior paint, and luxury vinyl flooring. Outdoors, enjoy the 30,000-gallon pool, multiple decks, and direct access to the creek below. With timeless design, enduring craftsmanship, and unmatched privacy, this Shands Woods retreat blends the best of nature and convenience - minutes to UF, Shands, the VA, and downtown, yet worlds away from it all.